Born into the famed Uzumaki clan of Uzushiogakure, Kushina lived most of her youth being caught-up in war, making her seek for a daily "peace". At a young age she was sent to Konoha and enrolled in the village's Ninja Academy. Wanting to make a strong first impression, she proclaimed to her class that she would be the first female Hokage. The other kids laughed at her statement, and began calling her Tomato (トマト) because of her then-round face and fiery red hair. This prompted her to lash out and pummel the kids who teased her. This, in addition to her red hair flowing wildly around, earned her the nickname of Red Hot-Blooded Habanero
(赤い血潮のハバネロ, Akai Chishio no Habanero).
Sometime after arriving in Konoha, Kushina was kidnapped by Kumogakure ninja who wanted to make use of her special chakra. As they escorted her to Kumo she secretly plucked and left behind strands of her red hair to mark her trail in the hopes that someone would find her. Minato Namikaze, one of her classmates that Kushina believed to be a wimp, was the only one to pick up on this. After rescuing her he informed her that he had always admired her red hair. Since Minato proved himself to be anything but a "wimp" and liked the one thing she hated about herself, Kushina fell in love with him. Kushina was eventually told why she was forced to leave her home of Uzushio and go to Konoha; because of her special chakra, she was to be the next jinchūriki of the Nine-Tailed Demon Fox. Kushina was terrified by the idea, but she was comforted by the Nine-Tails' then-current jinchūriki, Mito Uzumaki. Before the transfer was performed, Mito told Kushina that love was the only way to tame the Nine-Tails and overcome its hate. The love of Minato helped her do so. As she grew up Kushina became renowned for her beauty and unique ninjutsu style, including the fūinjutsu of her clan. At some point, Kushina married Minato and they conceived a son. During her ten-month jinchūriki pregnancy, they decided to name him "Naruto" after the main character of Jiraiya's first book. When Jiraiya asked if they were sure, stating that it was a name he came up with while eating a bowl of ramen, Kushina said that it was a beautiful name. They even chose Jiraiya to be Naruto's godfather. Kushina also hoped that her son and Mikoto Uchiha's youngest son Sasuke.